Biomonitoring of fast-elimination endocrine disruptors – Results from a 6-month follow up on human volunteers with repeated urine and hair collection

The assessment of human exposure to fast-elimination endocrine disruptors (ED) such as phthalates, bisphenols or pesticides is usually based on urinary biomarkers. variability biomarkers concentration, due rapid elimination from the body combined with frequent however pointed out a major limitation assessment. Other matrices hair, less sensitive short-term variations in exposure, have been proposed possible alternatives. Nevertheless, no study compared information obtained hair and urine respectively follow-up allowing assess over time these two matrices, compare correlation between them. In present study, samples were collected 16 volunteers 6 months follow-up. All all, 92 805 urines analyzed for presence phthalate metabolites, 4 8 pesticides/metabolites. detected at least one matrices. 21 more frequently urine, 1 was equivalent. Biomarkers intraclass coefficients (ICC) ranged 0.1 0.8 (ten above 0.4) 0.09 0.51 (two 0.4). concentrations significantly correlated only compound. This highlights complexity assessing ED suggests considering caution specificity matrix data interpretation. results document respective advantages limitations provide new insight understanding provided by biological their relevance fast contaminants. months, tested pesticides. 19 (in hair) 24 urine) >50% samples.